2-Methyl-2H-indazole-4-carboxylic acid methyl ester
2-Methyl-2H-indazole-4-carboxylic acid methyl ester
CAS: 1071428-43-7
Molecular Formula: C10H10N2O2
2-Methyl-2H-indazole-4-carboxylic acid methyl ester - Names and Identifiers
2-Methyl-2H-indazole-4-carboxylic acid methyl ester - Physico-chemical Properties
| Molecular Formula | C10H10N2O2 |
| Molar Mass | 190.2 |
| Storage Condition | 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD11109405 |
2-Methyl-2H-indazole-4-carboxylic acid methyl ester - Risk and Safety
| WGK Germany | 3 |
2-Methyl-2H-indazole-4-carboxylic acid methyl ester - Introduction
Acid methyl ester is an organic compound with the chemical formula C10H9N3O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: acid methyl ester is white to off-white crystal or crystalline powder.
-Solubility: Soluble in some organic solvents (such as chloroform, dichloromethane, ethanol, etc.), but low solubility in water.
-Melting point: Its melting point range is 112-115°C.
-Stability: The compound is relatively stable.
Use:
acrylic ester is often used as an intermediate in organic synthesis reactions. Because of its structure containing indazole ring and methyl group, it has certain potential as drug molecular skeleton or drug precursor in pharmaceutical chemistry.
Preparation Method:
The preparation method of acid methyl ester can be carried out by the following steps:
1.2-methyl -4-nitroindazole is reacted with methanol to generate 2-methyl -4-nitrosoindazole.
2. react 2-methyl -4-nitrosoindazole with HCl to generate 2-methyl -4-chloro nitrosoindazole. Br> 3. react 2-methyl -4-chloronitroindazole with sodium methoxide to generate acid ester.
Safety Information:
No detailed information has been provided on the acute toxicity data for acid ester. However, when handling and using the compound, strict laboratory safety practices should still be observed, such as wearing appropriate personal protective equipment (e. g. glasses, gloves) and ensuring adequate laboratory ventilation.
Nature:
-Appearance: acid methyl ester is white to off-white crystal or crystalline powder.
-Solubility: Soluble in some organic solvents (such as chloroform, dichloromethane, ethanol, etc.), but low solubility in water.
-Melting point: Its melting point range is 112-115°C.
-Stability: The compound is relatively stable.
Use:
acrylic ester is often used as an intermediate in organic synthesis reactions. Because of its structure containing indazole ring and methyl group, it has certain potential as drug molecular skeleton or drug precursor in pharmaceutical chemistry.
Preparation Method:
The preparation method of acid methyl ester can be carried out by the following steps:
1.2-methyl -4-nitroindazole is reacted with methanol to generate 2-methyl -4-nitrosoindazole.
2. react 2-methyl -4-nitrosoindazole with HCl to generate 2-methyl -4-chloro nitrosoindazole. Br> 3. react 2-methyl -4-chloronitroindazole with sodium methoxide to generate acid ester.
Safety Information:
No detailed information has been provided on the acute toxicity data for acid ester. However, when handling and using the compound, strict laboratory safety practices should still be observed, such as wearing appropriate personal protective equipment (e. g. glasses, gloves) and ensuring adequate laboratory ventilation.
Last Update：2024-04-09 20:13:35
